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Review
. 2006 Sep 8;241(1):23-30.
doi: 10.1016/j.canlet.2005.10.020. Epub 2005 Nov 21.

Delivery of hypericin for photodynamic applications

Constance Lay Lay Saw  1 , Malini Olivo, Khee Chee Soo, Paul Wan Sia Heng
Affiliations
Review

Delivery of hypericin for photodynamic applications

Constance Lay Lay Saw et al. Cancer Lett. .

Abstract

Early cancer detection is critical in improving disease management outcomes. Cancer diagnosis presents unique difficulties mainly due to its pathological presentation and poor accessibility that could limit the usefulness of conventional white light endoscopy in early cancer detection. Fluorescence endoscopy has been proven to improve the sensitivity and specificity of early cancer detection. Hypericin (HY) has been found to be superior to 5-aminolevulinic acid (5-ALA) and its ester derivative hexaminolevulinate (HA) as a fluorescence diagnostic agent, hence its development for delivery in vitro and in vivo, is the subject of this review.

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