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. 1975 Jan 24;187(4173):261-3.
doi: 10.1126/science.163038.

Collagenase production by lymphokine-activated macrophages

L M Wahl, S M Wahl, S E Mergenhagen, G R Martin

Collagenase production by lymphokine-activated macrophages

L M Wahl et al. Science. .

Abstract

Macrophages incubated with products (lymphokines) secreted by stimulated spleen cells produced collagenase. Active lymphokines were obtained both from mitogen- and antigen-stimulated lymphocytes. These observations suggest that the degradation of collagen in chronic inflammatory lesions may be caused by macrophage collagenase.

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