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Review
. 2005 Dec;49(12):4821-33.
doi: 10.1128/AAC.49.12.4821-4833.2005.

Prospects for aminoacyl-tRNA synthetase inhibitors as new antimicrobial agents

Julian Gregston Hurdle  1 , Alexander John O'Neill, Ian Chopra
Affiliations
Review

Prospects for aminoacyl-tRNA synthetase inhibitors as new antimicrobial agents

Julian Gregston Hurdle et al. Antimicrob Agents Chemother. 2005 Dec.
No abstract available

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Figures

FIG. 1.
FIG. 1.
Pleiotropic effects associated with activation of the stringent response following inhibition of aminoacyl-tRNA synthetases (20). PL, phospholipid; PG, peptidoglycan.
FIG. 2.
FIG. 2.
Chemical structures of mupirocin (structure 1), isoleucyl-AMP (Ile-AMP; structure 2), and mupirocin derivatives (structures 3 and 4).
FIG. 3.
FIG. 3.
(A) Comparative views of bound structures of mupirocin (top) and reactive intermediate (red; bottom) and superposition of the structures (middle) in the IleRS of S. aureus. Details of the binding pockets for mupirocin (B) and the acylated intermediate (C) and the positions of mupirocin resistance mutations are also shown. (Reprinted from reference .)
FIG. 4.
FIG. 4.
Chemical structures of l-tryptophan (structure 5), indolmycin (structure 6), chuangxinmycin (structure 7), borrelidin (structure 8), granaticin (structure 9), furanomycin (structure 10), ochratoxin A (structure 11), and cispentacin (structure 12).
FIG. 5.
FIG. 5.
Chemical structures of l-prolyl-sulfamoyl adenosine (structure 13), CB432 (structure 14), quinolinone derivative (structure 15), REP8839 (structure 16), phenylthiourea sulfonamide derivative (structure 17), and SB-203207 (structure 18).
See this image and copyright information in PMC

References

    1. Alovero, F., M. Nieto, M. R. Mazzieri, R. Then, and R. H. Manzo. 1998. Mode of action of sulfanilyl fluoroquinolones. Antimicrob. Agents Chemother. 42:1495-1498. - PMC - PubMed
    1. Andersson, D. I. 2003. Persistence of antibiotic resistant bacteria. Curr. Opin. Microbiol. 6:452-456. - PubMed
    1. Andersson, D. I., and B. R. Levin. 1999. The biological cost of antibiotic resistance. Curr. Opin. Microbiol. 2:489-493. - PubMed
    1. Antonio, M., N. McFerran, and M. J. Pallen. 2002. Mutations affecting the Rossman fold of isoleucyl-tRNA synthetase are correlated with low-level mupirocin resistance in Staphylococcus aureus. Antimicrob. Agents Chemother. 46:438-442. - PMC - PubMed
    1. Bacher, J. M., V. de Crecy-Lagard, and P. R. Schimmel. 2005. Inhibited cell growth and protein functional changes from an editing-defective tRNA synthetase. Proc. Natl. Acad. Sci. USA 102:1697-1701. - PMC - PubMed

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