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. 2005:340-5.
doi: 10.1182/asheducation-2005.1.340.

MGUS and smoldering multiple myeloma: update on pathogenesis, natural history, and management

S Vincent Rajkumar  1
Affiliations

MGUS and smoldering multiple myeloma: update on pathogenesis, natural history, and management

S Vincent Rajkumar. Hematology Am Soc Hematol Educ Program. 2005.

Abstract

Monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) are asymptomatic, pre-malignant disorders characterized by monoclonal plasma cell proliferation in the bone marrow and absence of end-organ damage. Recent advances in the pathogenesis, natural history, and prognosis of MGUS and SMM are reviewed. A new risk stratification system to determine the prognosis of MGUS using the size and type of M protein, and the serum free light chain assay is discussed.

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