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. 2005 Dec;60(6):629-31.
doi: 10.1111/j.1365-2125.2005.02498.x.

Gender specific association of CYP2C9*3 with hyperlipidaemia in Chinese

Chen-Hui Luo  1 , An Wang, Rong-Hua Zhu, Wei-Xia Zhang, Wei Mo, Bang-Ning Yu, Guo-Lin Chen, Dong-Sheng Ou-Yang, Xiao-Hong Duan, A M Abd El-Aty, Hong-Hao Zhou
Affiliations

Gender specific association of CYP2C9*3 with hyperlipidaemia in Chinese

Chen-Hui Luo et al. Br J Clin Pharmacol. 2005 Dec.

Abstract

Aims: To investigate the association of CYP2C9*3 and *6 with hyperlipidaemia in Chinese.

Methods: Four hundred and seventy-six Chinese participated in the study, including 211 uncomplicated hyperlipidaemic patients and 265 healthy controls. PCR-RFLP was used to identify CYP2C9*3 and *6.

Results: CYP2C9*6 was not detected in this study. The allelic frequency of CYP2C9*3 was 0.039 (95% CI 0.022, 0.056). A nonsignificant difference existed in CYP2C9*3 frequencies between males and females (P = 0.605, OR = 1.194, 95% CI 0.610, 2.336), patients and controls (P = 0.063, OR = 0.506, 95% CI 0.244, 1.049) in the total population. However, in the female group, CYP2C9*3 frequency in patients with hyperlipidaemia was significantly lower than that in controls (P < 0.0001, OR = 0.062, 95% CI 0.008, 0.476).

Conclusions: The association of CYP2C9*3 with hyperlipidaemia was specific for females in this Chinese population.

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References

    1. O'Brien T, Nguyen TT. Lipids and lipoproteins in women. Mayo Clin Proc. 1997;72:235–44. - PubMed
    1. Davidson MH, Maki KC, Karp SK, Ingram KA. Management of hypercholesterolaemia in postmenopausal women. Drugs Aging. 2002;19:169–78. - PubMed
    1. Cheng ZN, Shu Y, Liu ZQ, Wang LS, Ou-Yang DS, Zhou HH. Role of cytochrome P450 in estradiol metabolism in vitro. Acta Pharmacol Sin. 2001;22:148–54. - PubMed
    1. Yamazaki H, Shaw PM, Guengerich FP, Shimada T. Roles of cytochromes P450 1A2 and 3A4 in the oxidation of estradiol and estrone in human liver microsomes. Chem Res Toxicol. 1998;11:659–65. - PubMed
    1. Goldstein JA. Polymorphisms in the human CYP2C subfamily. Drug Metabolism Rev. 2002;34(Suppl 1):5.

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