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. 2005 Nov;20(11):1032-7.
doi: 10.1111/j.1525-1497.2005.0241.x.

The outcomes among patients presenting in primary care with a physical symptom at 5 years

Jeffrey L Jackson  1 , Mark Passamonti
Affiliations

The outcomes among patients presenting in primary care with a physical symptom at 5 years

Jeffrey L Jackson et al. J Gen Intern Med. 2005 Nov.

Abstract

Background: Symptoms are common and often remain medically unexplained.

Objective: To assess 5-year symptom outcomes, determine how often symptoms remain unexplained and assess their relationship with mental disorders.

Design: Prospective cohort study.

Participants: Five hundred consecutive patients presenting to a medicine clinic with physical symptoms. MEASUREMENTS PREVISIT: Mental disorders, symptom characteristics, stress, expectations, illness worry, and functional status. Postvisit (immediately, 2 weeks, 3 months, 5 years): unmet expectations, satisfaction, symptom outcome, functional status, and stress.

Results: While most subjects (81%) experienced symptom improvement by 5 years, resolution rates were lower (56%), with 35% of symptoms remained medically unexplained. Most patients with medically unexplained symptoms (MUS) did not have a mental disorder. Mood or anxiety disorders were not associated with MUS (relative risks [RR]: 0.94, 95% confidence interval [CI]: 0.79 to 1.13), or with lower rates of symptom improvement (RR: 1.14, 95% CI: 0.60 to 2.2). In contrast, most patients with somatoform disorders had MUS and were unlikely to improve. Worse functioning (RR: 0.95, 95% CI: 0.91 to 0.99), longer duration of symptom at presentation (RR: 0.5, 95% CI: 0.28 to 0.87), illness worry at presentation (RR: 0.56, 95% CI: 0.35 to 0.89), or lack of resolution by 3 months (RR: 0.47, 95% CI: 0.26 to 0.86) reduced the likelihood of symptom improvement at 5 years.

Conclusions: More than half of patients presenting with a physical symptom resolve by 5 years, while a third remain medically unexplained. Most patients whose symptom remained unexplained had no mental disorder. While mood and anxiety disorders were not associated with MUS or worse outcomes, most patients with somatoform disorders had MUS and were unlikely to improve.

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Figures

FIGURE 1
FIGURE 1
Study timeline and participation rates.
FIGURE 2
FIGURE 2
Symptom treatment algorithm.
See this image and copyright information in PMC

References

    1. Schappert SM, Nelson C. National Ambulatory Medical Care Survey 1995–96 summary. Vital Health Stat. 1999;13:1–122. - PubMed
    1. Von Korff M, Deyo RA, Cherkin D, Barlow W. Back pain in primary care: outcomes at one year. Spine. 1993;18:855–62. - PubMed
    1. Valdini AF, Steinhardt S, Valicenti J, Jaffe A. One-year follow up of fatigued patients. J Fam Pract. 1998;26:33–8. - PubMed
    1. Kroenke K, Lucas CA, Rosenberg ML, Scherokman BJ, Herbers JE. One-year outcome in patients with a chief complaint of dizziness. J Gen Intern Med. 1994;9:684–9. - PubMed
    1. Weber BE, Kapoor WN. Evaluation and outcomes of patients with palpitations. Am J Med. 1996;100:138–48. - PubMed