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Case Reports
. 2006 Jan 15;240(1-2):107-10.
doi: 10.1016/j.jns.2005.09.003. Epub 2005 Nov 22.

Heredity in multiple system atrophy

Hiroyuki Soma  1 , Ichiro Yabe, Asako Takei, Naoto Fujiki, Tetsuro Yanagihara, Hidenao Sasaki
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Free article
Case Reports

Heredity in multiple system atrophy

Hiroyuki Soma et al. J Neurol Sci. .
Free article

Abstract

We investigated the family histories of 157 Japanese patients with probable or possible multiple system atrophy (MSA). A family history of neurodegenerative disorders was only detected in three MSA patients (1.9%). We evaluated these patients by careful neurological examination, neuroimaging studies, and genetic studies to exclude hereditary spinocerebellar ataxia with a similar clinical phenotype to MSA. The results indicated that one of them had a family history of MSA. Although the familial presence of neurodegenerative disorders is rare in MSA patients, the existence of such cases suggests that MSA may have a genetic background.

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