[Hepatitis B virus markers and anti-HCV antibodies in hemodialyzed patients]

Abstract

Serum samples from 155 patients on haemodialysis were examined for markers of hepatitis B and C. Abbott and Ortho Elisa tests were used for the determinations. ALT levels were analysed at the same time. Of the 345 random blood donors and 366 prisoners examined, 1.44% proved to be anti-HCV antibody positive. 13 medical staff workers of 147 were found to be positive for anti-HCV antibody (19.1%). In patients on chronic haemodialysis 41.29% anti-HCV antibody prevalence was found. The prevalence of anti-HBc and anti-HCV antibodies in correlation with the number of transfusions was examined as well, in serums of chronic uraemic patients. Anti-HBc antibody prevalence was significantly higher in the polytransfused group (p less than 0.01), compared to the group without transfusion. There were no correlation between the number of transfusions and anti-HCV antibody occurrence. ALT values were in correlation with HBV and HCV seropositives. Elevated ALT levels were found in patients with HBV and/or HCV infection. In conclusion, screening for HBV and HCV markers among patients receiving blood, blood donors and medical staff workers seems to be necessary in the future. The results suggest the determination of anti-HBc to be an early and common marker of hepatitis B and C and the frequent occurrence of nosocomial transmission and the importance of prevention at high risk patients.