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Review
. 1992 Jun 19;14(3):61-77.
doi: 10.1007/BF01962689.

Platinum antitumour agents: a review of (bio)analysis

T J Hodes  1 , W J Underberg, G Los, J H Beijnen
Affiliations
Review

Platinum antitumour agents: a review of (bio)analysis

T J Hodes et al. Pharm Weekbl Sci. .

Abstract

This paper summarizes analytical techniques in order to get a clear picture of the ins and outs of the (bio)analysis of platinum-containing compounds. The antitumour agent cisplatin has become an indispensable drug for the cure of a variety of cancer diseases. Since its introduction in the early seventies, about 2,000 related platinum complexes were designed to devoid the dose-limiting nephrotoxicity. Some of them were introduced for clinical trial, such as carboplatin and iproplatin. To investigate the mechanism of action and pharmaco-kinetic behaviour, several interesting assays for total and specific platinum determination in biological matrices have been developed, each with its own possibilities and limitations.

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References

    1. Clin Chem. 1978 Jun;24(6):877-80 - PubMed
    1. J Anal Toxicol. 1987 Nov-Dec;11(6):242-6 - PubMed
    1. Cancer Chemother Pharmacol. 1986;18(2):129-32 - PubMed
    1. Cancer Chemother Pharmacol. 1989;23(1):37-40 - PubMed
    1. Anal Biochem. 1982 Jul 15;124(1):167-79 - PubMed