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Review
. 2005 Nov;287(1):42-8.
doi: 10.1002/ar.b.20084.

Eye on regeneration

Mindy K Call  1 , Matthew W Grogg, Panagiotis A Tsonis
Affiliations
Review

Eye on regeneration

Mindy K Call et al. Anat Rec B New Anat. 2005 Nov.

Abstract

Lens regeneration in newts is a remarkable process, whereby a lost tissue is replaced by transdifferentiation of adult tissues that only a few organisms possess. In this review, we will touch on the approaches being used to study this phenomenon, recent advances in the field of lens regeneration, similarities and differences between development and regeneration, as well as the potential role stem cells may play in understanding this process.

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Figures

Figure 1
Figure 1
Lens regeneration in the newt stemming from the PECs of the dorsal iris (di). A. 10 days post-lentectomy. Note the formation of a lens vesicle (arrow). B. 15 days post-lentectomy. Cells are elongating into lens fibers. C. 20 days post-lentectomy. The lens is well differentiated with lens fibers.
Figure 2
Figure 2
Comparison of lens development with two methods of lens regeneration. A. Schematic showing lens development, which involves a series of inductive interactions between the surface ectoderm and the optic cup. The lens pit eventually gives rise to the lens. se: surface ectoderm, oc: optic cup. B. Lens regeneration in Xenopus laevis. The regenerated lens comes from transdifferentiation of cells in the outer cornea (c). C. Lens regeneration in the newt. The regenerated lens comes from transdifferentiation of cells in the dorsal iris.
See this image and copyright information in PMC

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