Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Nov;68(11):1592-7.
doi: 10.1021/np050293f.

Using jasplakinolide to turn on pathways that enable the isolation of new chaetoglobosins from Phomospis asparagi

Omar E Christian  1 , Jennifer Compton, Keisha R Christian, Susan L Mooberry, Fredrick A Valeriote, Phillip Crews
Affiliations

Using jasplakinolide to turn on pathways that enable the isolation of new chaetoglobosins from Phomospis asparagi

Omar E Christian et al. J Nat Prod. 2005 Nov.

Abstract

The isolation and structure elucidation of three new secondary metabolites, chaetoglobosin-510 (1), -540 (2), and -542 (3), are described. These compounds were produced by cultures of the marine-derived fungus Phomopsis asparagi, challenged with the known F-actin inhibitor jasplakinolide. Chaetoglobosin-542 (3) displayed antimicrofilament activity and was cytotoxic toward murine colon and leukemia cancer cell lines.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Comparison of the ELSD trace of crude extract of P. asparagi culture conditions, untreated (A) vs inoculated with jasplakinolide (B).
Figure 2
Figure 2
Substructures A–D with selected gHMBC and gCOSY correlations for 1.
Figure 3
Figure 3
Portions of 1 confirmed by TOCSY.
See this image and copyright information in PMC

References

    1. Firn RD, Jones CG. Nat Prod Rep. 2003;20:382–391. - PubMed
    1. Cerda-Olmedo E. Crit Rev Micobiol. 1994;20:151–160. - PubMed
    2. Firn RD, Jones CG. Mol Microbiol. 2000;37:989–994. - PubMed
    1. Hutchinson CR. Proc Natl Acad Sci USA. 1999;96:3336–3338. - PMC - PubMed

    1. This approach has been named OSMAC: Bode HB, Bethe B, Höfs R, Zeeck A. ChemBioChem. 2002;3:691–627.

    1. Preisg CL, Laakso JA, Mocek UM, Wang PT, Baez J, Byng G. J Nat Prod. 2003;66:350–356. - PubMed
    2. Okuno Y, Miyazawa M. J Nat Prod. 2004;67:1876–1878. - PubMed
    3. Zhang J, Cheng ZH, Yu BY, Cordell GA, Qiu SX. Tetrahedron Lett. 2005;46:2337–2340.
    4. Tian Y, Guo H, Han J, Guo D. J Nat Prod. 2005;68:678–680. - PubMed

Publication types