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. 2005 Dec;53(6):993-1001.
doi: 10.1016/j.jaad.2005.07.045.

Soft x-ray therapy for cutaneous basal cell and squamous cell carcinomas

Klaus-Werner Schulte, Andrea Lippold, Christine Auras, Gernot Bramkamp, Claudia Breitkopf, Heinz-Joachim Elsmann, Eva Maria Habenicht, Volker Jasnoch, Helga Müller-Pannes, Rainer Rupprecht, Ludwig Suter

Soft x-ray therapy for cutaneous basal cell and squamous cell carcinomas

Klaus-Werner Schulte et al. J Am Acad Dermatol. 2005 Dec.

Abstract

Background: We have used a schedule for soft x-ray therapy of epithelial malignancies that takes into account the clinically diagnosed tumor involution under treatment.

Objective: We sought to evaluate the effectiveness of this schedule in terms of cure rate and late ulcerations.

Methods: Patients with 1267 consecutively irradiated (1988-1992) basal cell and squamous cell carcinomas were followed up (average 77 months).

Results: The recurrence rate (5.1%) was related to tumor size and thickness and to the time-dose-fractionation factor. The frequency of ulcerations (6.3%) depended on field size, hardness of the x-rays, and in smaller fields (diameter up to 4 cm) on total dose, and time-dose-fractionation factor. Of all ulcerations, 82.5 % could be conservatively cured.

Limitations: We have no evidence that our radiation schedule is superior to those published by other authors.

Conclusion: These results verify the usefulness of soft x-ray therapy for cutaneous epithelial malignancies.

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