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. 1992 Jul 1;89(13):6006-9.
doi: 10.1073/pnas.89.13.6006.

Folate receptor allows cells to grow in low concentrations of 5-methyltetrahydrofolate

H Matsue  1 , K G Rothberg, A Takashima, B A Kamen, R G Anderson, S W Lacey
Affiliations

Folate receptor allows cells to grow in low concentrations of 5-methyltetrahydrofolate

H Matsue et al. Proc Natl Acad Sci U S A. .

Abstract

The folate receptor mediates the uptake of 5-methyltetrahydrofolate in certain cultured cells by a process called potocytosis. When these cells are grown in physiological concentrations of folate, the receptor increases the efficiency of vitamin uptake by 30-fold. We now show that PAM 212 cells, a mouse keratinocyte cell line, are unable to grow in 1 nM 5-methyltetrahydrofolate unless they express a functional folate receptor. These results suggest that under certain conditions, tissue cells in the body may depend on the folate receptor to obtain enough 5-methyltetrahydrofolate for growth.

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References

    1. J Biophys Biochem Cytol. 1955 Sep 25;1(5):445-58 - PubMed
    1. Anal Biochem. 1976 May 7;72:248-54 - PubMed
    1. Cell. 1992 Feb 21;68(4):673-82 - PubMed
    1. J Clin Invest. 1991 Apr;87(4):1442-9 - PubMed
    1. Cancer Res. 1991 Nov 15;51(22):6125-32 - PubMed

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