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Comparative Study
. 2005 Dec;11(12):1287-9.
doi: 10.1038/nm1329. Epub 2005 Nov 27.

A role for LEDGF/p75 in targeting HIV DNA integration

Angela Ciuffi  1 , Manuel Llano, Eric Poeschla, Christian Hoffmann, Jeremy Leipzig, Paul Shinn, Joseph R Ecker, Frederic Bushman
Affiliations
Comparative Study

A role for LEDGF/p75 in targeting HIV DNA integration

Angela Ciuffi et al. Nat Med. 2005 Dec.

Abstract

HIV DNA integration is favored in active genes, but the underlying mechanism is unclear. Cellular lens epithelium-derived growth factor (LEDGF/p75) binds both chromosomal DNA and HIV integrase, and might therefore direct integration by a tethering interaction. We analyzed HIV integration in cells depleted for LEDGF/p75, and found that integration was (i) less frequent in transcription units, (ii) less frequent in genes regulated by LEDGF/p75 and (iii) more frequent in GC-rich DNA. LEDGF is thus the first example of a cellular protein controlling the location of HIV integration in human cells.

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