FSH, the neglected sibling: evidence for its role in regulation of spermatogenesis and Leydig cell function
- PMID: 16313062
FSH, the neglected sibling: evidence for its role in regulation of spermatogenesis and Leydig cell function
Abstract
The role of follicle stimulating harmone(FSH) in male reproductive function remains a matter of debate although recent evidences strongly suggest a role despite the controversies that arose following the results obtained with FSH-beta null mice and observations from human FSH receptor mutations. This review summarizes the recent developments of our understanding on the role of FSH in male reproduction. Specifically the results obtained with FSH-beta and FORKO null mice are be discussed in light of our observations employing active and passive neutralization of endogenous FSH in rodents and primates along with other studies. On the basis of results obtained employing a variety of models it can be conclude unequivocally that FSH regulates Leydig cell function and is essential for normal quantitative spermatogenesis.
Similar articles
-
Constitutively active follicle-stimulating hormone receptor enables androgen-independent spermatogenesis.J Clin Invest. 2018 May 1;128(5):1787-1792. doi: 10.1172/JCI96794. Epub 2018 Mar 26. J Clin Invest. 2018. PMID: 29584617 Free PMC article.
-
The role of follicle-stimulating hormone in spermatogenesis: lessons from knockout animal models.Arch Med Res. 2001 Nov-Dec;32(6):601-8. doi: 10.1016/s0188-4409(01)00328-9. Arch Med Res. 2001. PMID: 11750736 Review.
-
Role of androgen and gonadotrophins in the development and function of the Sertoli cells and Leydig cells: data from mutant and genetically modified mice.Mol Cell Endocrinol. 2009 Jul 10;306(1-2):2-8. doi: 10.1016/j.mce.2008.11.005. Epub 2008 Nov 18. Mol Cell Endocrinol. 2009. PMID: 19059463 Review.
-
Fertility and spermatogenesis are altered in {alpha}1b-adrenergic receptor knockout male mice.J Endocrinol. 2007 Nov;195(2):281-92. doi: 10.1677/JOE-07-0071. J Endocrinol. 2007. PMID: 17951539
-
FSH-sensitive murine sertoli cell lines immortalized by human telomerase gene hTERT express the androgen receptor in response to TNF-alpha stimulation.Biosci Rep. 2007 Dec;27(6):403-11. doi: 10.1007/s10540-007-9063-y. Epub 2007 Oct 30. Biosci Rep. 2007. PMID: 17968653
Cited by
-
From Fertilisation to Implantation in Mammalian Pregnancy-Modulation of Early Human Reproduction by the Endocannabinoid System.Pharmaceuticals (Basel). 2010 Sep 2;3(9):2910-2929. doi: 10.3390/ph3092910. Pharmaceuticals (Basel). 2010. PMID: 27713383 Free PMC article. Review.
-
The preparation and application of N-terminal 57 amino acid protein of the follicle-stimulating hormone receptor as a candidate male contraceptive vaccine.Asian J Androl. 2014 Jul-Aug;16(4):623-30. doi: 10.4103/1008-682X.125910. Asian J Androl. 2014. PMID: 24713829 Free PMC article.