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. 2006 Aug;53(2):e65-7.
doi: 10.1016/j.jinf.2005.10.013. Epub 2005 Nov 28.

Transient clonal expansion of T-large granular lymphocytes during primary cytomegalovirus infection

Pierre Delobel  1 , Aurélie Godel, Sophie Thebault, Laurent Alric, Michel Duffaut
Affiliations

Transient clonal expansion of T-large granular lymphocytes during primary cytomegalovirus infection

Pierre Delobel et al. J Infect. 2006 Aug.

Abstract

Clonal immunoglobulin and T-cell receptor gene rearrangements are useful in distinguishing reactive lymphoproliferations from neoplastic processes. Here, we report a case of transient clonal expansion of CD8+ CD57- T-large granular lymphocytes (T-LGL) during primary cytomegalovirus infection. This case underlines that clonal expansion of T-LGL could be a reactive phenomenon related to an acute infectious disease and is not specific for lymphoid malignancy.

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