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. 2006 Mar 15;107(6):2531-5.
doi: 10.1182/blood-2005-04-1768. Epub 2005 Nov 29.

Neoplastic circulating endothelial cells in multiple myeloma with 13q14 deletion

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Free article

Neoplastic circulating endothelial cells in multiple myeloma with 13q14 deletion

Gian Matteo Rigolin et al. Blood. .
Free article

Abstract

In multiple myeloma (MM), circulating endothelial cells (CECs) represent a vascular marker of angiogenesis and may reflect tumor mass. In this report, we showed that, in 5 MM patients with 13q14 deletion, CECs carried the same chromosome aberration as the neoplastic plasma cells (11%-32% of CECs with 13q14 deletion). Most of the CECs displayed immunophenotypic features of endothelial progenitor cells as they expressed CD133, a marker gradually lost during endothelial differentiation and absent on mature endothelial cells. To the contrary, in 3 patients with monoclonal gammopathy of undetermined significance and 13q14 deletion, CECs were cytogenetically normal and had a mature immunophenotype. In MM CECs, immunoglobulin genes were clonally rearranged. These findings suggest a possible origin of CECs from a common hemangioblast precursor that can give rise to both plasma cells and endothelial cells and point to a direct contribution of MM-derived CECs to tumor vasculogenesis and possibly to the spreading and progression of the disease.

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  • Lineage complexity in multiple myeloma?
    Sahota SS, Stevenson FK. Sahota SS, et al. Leuk Lymphoma. 2006 Sep;47(9):1997-8. doi: 10.1080/10428190600758686. Leuk Lymphoma. 2006. PMID: 17065026 Review. No abstract available.

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