Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Autumn;15(4 Suppl 6):S6-30-37.

Study design for genetic analysis in the Jackson Heart Study

James G Wilson  1 , Charles N Rotimi, Lynette Ekunwe, Charmaine D M Royal, Mary E Crump, Sharon B Wyatt, Michael W Steffes, Adebowale Adeyemo, Jie Zhou, Herman A Taylor Jr, Cashell Jaquish
Affiliations
  • PMID: 16317983

Study design for genetic analysis in the Jackson Heart Study

James G Wilson et al. Ethn Dis. 2005 Autumn.

Abstract

Objective: This paper describes the preparation of genetic materials and the recruitment and initial characterization of a nested Family Study within the Jackson Heart Study (JHS) METHODS: Genomic DNA was prepared from all consenting JHS participants. In addition, family members of a subset of JHS participants were recruited to the JHS Family Study to allow heritability and linkage analyses and family-based association studies. Family Study participants completed the same questionnaires, measures, and procedures as all other JHS participants and provided blood samples for lymphocyte cryopreservation and transformation.

Results: DNA samples were obtained from 4726 JHS participants, including 1499 members of 291 families. In the family cohort, estimated heritabilities of body mass index, selected lipid levels, and blood pressure are highly significant, supporting the validity of the sample.

Discussion: The JHS data and genetic materials (DNA and cryopreserved cells) offer valuable opportunities to identify susceptibility alleles for common complex diseases by positional and candidate gene approaches.

PubMed Disclaimer

Publication types

MeSH terms