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. 2005 Nov;11(11):1680-5.
doi: 10.3201/eid1111.050575.

Cervical human papillomavirus screening among older women

Matthew J Grainge  1 , Rashmi Seth, Li Guo, Keith R Neal, Carol Coupland, Paul Vryenhoef, Jane Johnson, David Jenkins
Affiliations

Cervical human papillomavirus screening among older women

Matthew J Grainge et al. Emerg Infect Dis. 2005 Nov.

Abstract

Rates of acquisition and clearance of cervical human papillomavirus (HPV) during a 3-year period in women 51 years of age were compared with rates in younger women to provide data on cervical screening for women >50 years of age. Paired, cytologically negative, archived cervical smears taken 3 years apart from 710 women in Nottingham, United Kingdom, were retrieved and tested for HPV infection with polymerase chain reaction (PCR) with GP5+/6+ primers. Seventy-one (21.3%) of 333 women 51 years of age who were HPV negative at baseline were positive 3 years later. This percentage was higher than the corresponding acquisition rates among women 21 (15.2%), 31 (14.1%), and 41 (13.3%) years of age, although these differences were not significant. This retrospective study shows that HPV-negative women >50 years of age can acquire HPV and, therefore, require cervical screening.

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