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. 2006 Jan;37(1):243-5.
doi: 10.1161/01.STR.0000195184.24297.c1. Epub 2005 Dec 1.

Reduced vitamin D in acute stroke

Kenneth E S Poole  1 , Nigel Loveridge, Peter J Barker, David J Halsall, Collette Rose, Jonathan Reeve, Elizabeth A Warburton
Affiliations

Reduced vitamin D in acute stroke

Kenneth E S Poole et al. Stroke. 2006 Jan.

Abstract

Background and purpose: Stroke leads to a reduction in bone mineral density, altered calcium homeostasis, and an increase in hip fractures. Vitamin D deficiency is well documented in long-term stroke survivors and is associated with post-stroke hip fractures. Less is known regarding levels in acute stroke.

Methods: We compared the serum 25-dihydroxyvitamin D levels of 44 patients admitted to an acute stroke unit with first-ever stroke with results obtained by measuring 96 healthy ambulant elderly subjects every 2 months for 1 year. Statistical Z scores of serum vitamin D were then calculated after seasonal adjustment for the month of sampling.

Results: The mean Z score of vitamin D in acute stroke was -1.4 SD units (95% CI, -1.7, -1.1), with 77% of patients falling in the insufficient range.

Conclusions: Reduced vitamin D was identified in the majority of patients with acute stroke throughout the year and may have preceded stroke. Vitamin D is a potential risk marker for stroke, and the role of vitamin D repletion in enhancing musculoskeletal health after stroke needs to be explored.

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