Review
doi: 10.1016/j.cell.2005.11.009.
Can 1000 reviews be wrong? Actin, alpha-Catenin, and adherens junctions
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- PMID: 16325573
- DOI: 10.1016/j.cell.2005.11.009
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Review
Can 1000 reviews be wrong? Actin, alpha-Catenin, and adherens junctions
Cell.
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Free article
Abstract
Coupling between cell adhesion and the actin cytoskeleton is thought to require a stable link between the cadherin-catenin complex and actin that is mediated by alpha-catenin. In this issue of Cell, the Weis and Nelson groups call this static model into question, showing that alpha-catenin can directly regulate actin dynamics (Drees et al., 2005 and Yamada et al., 2005).
Comment on
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Deconstructing the cadherin-catenin-actin complex.Cell. 2005 Dec 2;123(5):889-901. doi: 10.1016/j.cell.2005.09.020. Cell. 2005. PMID: 16325582 Free PMC article.
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Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly.Cell. 2005 Dec 2;123(5):903-15. doi: 10.1016/j.cell.2005.09.021. Cell. 2005. PMID: 16325583 Free PMC article.
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