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Review
. 2005 Dec;38(6):1215-36, ix.
doi: 10.1016/j.otc.2005.08.006.

Chronic rhinosinusitis and superantigens

Kristin A Seiberling  1 , Leslie Grammer, Robert C Kern
Affiliations
Review

Chronic rhinosinusitis and superantigens

Kristin A Seiberling et al. Otolaryngol Clin North Am. 2005 Dec.

Abstract

This article discusses the potential role of bacterial superantigens (SAgs) in chronic rhinosinusitis with nasal polyposis (CRS/NP). First, it briefly describes SAgs, focusing on how they interact with the immune system by binding to T-cell receptors (TCR) and major histocompatibility complex (MHC) class II molecules. Second, it discusses the role of SAgs in other chronic inflammatory diseases.Finally, it presents evidence for the role of SAgs in the pathogenesis and maintenance of CRS/NP focusing on current research and future considerations.

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