IFITM1-mediated cell repulsion controls the initial steps of germ cell migration in the mouse
- PMID: 16326382
- DOI: 10.1016/j.devcel.2005.11.009
IFITM1-mediated cell repulsion controls the initial steps of germ cell migration in the mouse
Abstract
In this issue of Developmental Cell, a novel mechanism for the initiation of germ cell migration in the mouse has been identified, based upon differential expression of interferon-inducible transmembrane proteins in the gastrula (Tanaka et al., 2005). Germ cells are displaced by a repulsion mechanism from the posterior mesoderm into the endoderm.
Comment on
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IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion.Dev Cell. 2005 Dec;9(6):745-56. doi: 10.1016/j.devcel.2005.10.010. Dev Cell. 2005. PMID: 16326387
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