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Comment
. 2005 Dec 15;106(13):4413; author reply 4414.
doi: 10.1182/blood-2005-07-2923.

The role of duodenal cytochrome b in intestinal iron absorption remains unclear

Comment

The role of duodenal cytochrome b in intestinal iron absorption remains unclear

David M Frazer et al. Blood. .
No abstract available

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Figures

Figure 1.
Figure 1.
Intestinal iron absorption and liver iron content in sla and C57BL/6J mice on an iron-deficient diet. Animals were maintained on an iron-deficient diet for 6 weeks from weaning, and iron absorption was determined by whole-body counting following the oral administration of radioactive iron as previously described. Absorption (▪) is presented as the percentage of the initial iron dose retained by the animals 5 days after dosing. Hepatic iron measurements (□) were performed on liver tissue as previously described. Data represent the mean ± SEM of 3 animals. Statistical differences were assessed using Student t test. P = .001 for iron absorption. P = .86 for liver iron content.

Comment on

References

    1. McKie AT, Barrow D, Latunde-Dada GO, et al. An iron-regulated ferric reductase associated with the absorption of dietary iron. Science. 2001;291: 1755-1759. - PubMed
    1. Gunshin H, Starr CN, DiRenzo C, et al. Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice. Blood. 2005;106: 2879-2883. - PMC - PubMed
    1. Vulpe CD, Kuo YM, Murphy TL, et al. Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse. Nat Genet. 1999;21: 195-199. - PubMed
    1. Pinkerton PH, Bannerman RM. Hereditary defect in iron absorption in mice. Nature. 1967;216: 482-483. - PubMed
    1. Frazer DM, Wilkins SJ, Becker EM, et al. Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats. Gastroenterology. 2002;123: 835-844. - PubMed