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. 2006 Jan;24(1):76-7.
doi: 10.1038/nbt1170. Epub 2005 Dec 4.

Production of a recombinant bacterial lipoprotein in higher plant chloroplasts

Karin Glenz  1 , Bernadette Bouchon, Thomas Stehle, Reinhard Wallich, Markus M Simon, Heribert Warzecha
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Production of a recombinant bacterial lipoprotein in higher plant chloroplasts

Karin Glenz et al. Nat Biotechnol. 2006 Jan.

Abstract

Little is known about the potential of plastids to accomplish post-translational modifications of foreign proteins. In the present study we generated transplastomic tobacco plants that accumulate the outer surface lipoprotein A (OspA)-the basic constituent of the first generation monovalent human vaccine against Lyme disease. The recombinant OspA exhibits a lipid modification typical for bacteria and induced protective antibodies in mice, demonstrating that functionally active bacterial lipoproteins can be processed in plants.

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