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Review
. 2006 Feb;448(2):111-8.
doi: 10.1007/s00428-005-0102-4. Epub 2005 Nov 23.

Current practice of Gleason grading of prostate carcinoma

Antonio Lopez-Beltran  1 , Gregor Mikuz, Rafael J Luque, Roberta Mazzucchelli, Rodolfo Montironi
Affiliations
Review

Current practice of Gleason grading of prostate carcinoma

Antonio Lopez-Beltran et al. Virchows Arch. 2006 Feb.

Abstract

The Gleason grading system remains one of the most powerful prognostic factors in prostate cancer and is the dominant method around the world in daily practice. It is based solely on the glandular architecture performed at low magnification. The Gleason grading system should be performed in needle core biopsies and radical prostatectomy specimens where it shows a reasonable degree of correlation between both specimens, and most importantly, it remains vital in the treatment decision-making process. This review summarizes the current status of Gleason grading in prostate cancer, incorporating recent proposals for the best contemporary practice of prostate cancer grading.

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