Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Dec;2(6):344-5.
doi: 10.1016/j.cmet.2005.11.011.

Osteoprotegerin, the bone protector, is a surprising target for beta-catenin signaling

Brendan F Boyce  1 , Lianping Xing, Di Chen
Affiliations

Osteoprotegerin, the bone protector, is a surprising target for beta-catenin signaling

Brendan F Boyce et al. Cell Metab. 2005 Dec.

Abstract

Osteoblasts influence bone mass by the amount of bone they synthesize and by regulating osteoclasts, the cells that degrade bone. In the December issue of Developmental Cell, Kieslinger et al. (2005) show that immature osteoblasts regulate expression of the osteoclast inhibitor, osteoprotegerin, through an early B cell factor and β-catenin signaling.

PubMed Disclaimer

References

    1. Glass DA, 2nd, Bialek P, Ahn JD, Starbuck M, Patel MS, Clevers H, Taketo MM, Long F, McMahon AP, Lang RA, Karsenty G. Dev Cell. 2005;8:751–764. - PubMed
    1. Hill TP, Spater D, Taketo MM, Birchmeier W, Hartmann C. Dev Cell. 2005;8:727–738. - PubMed
    1. Holmen SL, Zylstra CR, Mukherjee A, Sigler RE, Faugere MC, Bouxsein ML, Deng L, Clemens TL, Williams BO. J Biol Chem. 2005;280:21162–21168. - PubMed
    1. Huelsken J, Birchmeier W. Curr Opin Genet Dev. 2001;11:547–553. - PubMed
    1. Jackson A, Vayssiere B, Garcia T, Newell W, Baron R, Roman-Roman S, Rawadi G. Bone. 2005;36:585–598. - PubMed

LinkOut - more resources