Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2006 Jan;147(2):128-30.
doi: 10.1038/sj.bjp.0706501.

Fading of 5-HT4 receptor-mediated inotropic responses to 5-hydroxytryptamine is caused by phosphodiesterase activity in porcine atrium

Alberto J Kaumann  1 , Finn Olav Levy
Affiliations
Comment

Fading of 5-HT4 receptor-mediated inotropic responses to 5-hydroxytryptamine is caused by phosphodiesterase activity in porcine atrium

Alberto J Kaumann et al. Br J Pharmacol. 2006 Jan.

Abstract

Inotropic responses to 5-hydroxytryptamine (5-HT) in human and porcine atrium can fade, suggesting 5-HT(4) receptor desensitization. De Maeyer et al., however, show in this issue that inhibition of phosphodiesterases with isobutyl-methyl-xanthine prevents fading of 5-HT(4) receptor-mediated responses to 5-HT and the partial agonist prucalopride in porcine atrium.

PubMed Disclaimer

Comment on

Similar articles

See all similar articles

Cited by

References

    1. BACH T., SYVERSVEEN T., KVINGEDAL A.M., KROBERT K.A., BRATTELID T., KAUMANN A.J., LEVY F.O. 5-HT4(a) and 5-HT4(b) receptors have nearly identical pharmacology and are both expressed in human atrium and ventricle. Naunyn-Schmiedeberg's Arch. Pharmacol. 2001;363:146–160. - PubMed
    1. BRATTELID T., QVIGSTAD E., LYNHAM J.A., MOLENAAR P., AASS H., GEIRAN O., SKOMEDAL T., OSNES J.B., LEVY F.O., KAUMANN A.J. Functional serotonin 5-HT4 receptors in porcine and human ventricular myocardium with increased 5-HT4 mRNA in heart failure. Naunyn-Schmiedeberg's Arch. Pharmacol. 2004;370:157–166. - PubMed
    1. DE MAEYER J.H., STRAETMANN R., SCHUURKES J.A.J., LEFEBVRE R.A.Porcine left atrial and sinoatrial 5-HT4 receptor induced responses: fading of the response and influence of development Br. J. Pharmacol. 2005147140–157.(this issue) - PMC - PubMed
    1. JAHNEL U., RUPP J., ERTL R., NAWRATH H. Positive inotropic responses to 5-HT in human atrial but not in ventricular heart muscle. Naunyn-Schmiedeberg's Arch. Pharmacol. 1992;346:482–485. - PubMed
    1. JUAN-FITA M.J., VARGAS M.L., KAUMANN A.J., HERNANDEZ CASCALES J. Rolipram reduces the inotropic tachyphylaxis of glucagon in rat ventricular myocardium. Naunyn-Schmiedeberg's Arch. Pharmacol. 2004;370:324–329. - PubMed

Publication types

Substances