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Comment
. 2006 Jan;147(2):128-30.
doi: 10.1038/sj.bjp.0706501.

Fading of 5-HT4 receptor-mediated inotropic responses to 5-hydroxytryptamine is caused by phosphodiesterase activity in porcine atrium

Alberto J Kaumann  1 , Finn Olav Levy
Affiliations
Comment

Fading of 5-HT4 receptor-mediated inotropic responses to 5-hydroxytryptamine is caused by phosphodiesterase activity in porcine atrium

Alberto J Kaumann et al. Br J Pharmacol. 2006 Jan.

Abstract

Inotropic responses to 5-hydroxytryptamine (5-HT) in human and porcine atrium can fade, suggesting 5-HT(4) receptor desensitization. De Maeyer et al., however, show in this issue that inhibition of phosphodiesterases with isobutyl-methyl-xanthine prevents fading of 5-HT(4) receptor-mediated responses to 5-HT and the partial agonist prucalopride in porcine atrium.

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References

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