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Review
. 2007 Apr;48(4):479-82.
doi: 10.1002/pbc.20705.

Favorable histology, MYCN-amplified 4S neonatal neuroblastoma

Edward L Chan  1 , Richard E Harris, Kathleen H Emery, Michael J Gelfand, Margaret H Collins, Ralph A Gruppo
Affiliations
Review

Favorable histology, MYCN-amplified 4S neonatal neuroblastoma

Edward L Chan et al. Pediatr Blood Cancer. 2007 Apr.

Abstract

We report a neonate with 4S neuroblastoma and MYCN amplification, but favorable Shimada histology, successfully treated with chemotherapy and 13-cis-retinoic acid without stem cell transplantation. MYCN amplification in neuroblastoma is usually associated with unfavorable Shimada histology; the presence of these features in infants with 4S disease confers a poor prognosis. A small number of infants with 4S neuroblastoma and MYCN amplification have favorable Shimada histology. In this subgroup of infants, histopathology may be equally important in predicting outcome.

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