Review
doi: 10.1016/s0959-437x(05)80315-6.
Regulation of p21ras by GTPase activating proteins and guanine nucleotide exchange proteins
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- PMID: 1633420
- DOI: 10.1016/s0959-437x(05)80315-6
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Review
Regulation of p21ras by GTPase activating proteins and guanine nucleotide exchange proteins
Curr Opin Genet Dev.
1992 Feb.
Abstract
Ras proteins play a critical role in controlling normal cellular growth and, when activated by mutation, in causing malignant transformation. Regulation of p21ras is achieved by GTPase activating proteins, which control the rate of hydrolysis of GTP to GDP, and also by GDP dissociation stimulators, which catalyze the exchange of guanine nucleotides. Several such proteins have now been identified and their control mechanisms characterized.
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