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Review
. 2005 Nov;101(5 Suppl):S30-S43.
doi: 10.1213/01.ANE.0000177101.99398.22.

The role of intrathecal drugs in the treatment of acute pain

James P Rathmell  1 , Timothy R Lair, Bushra Nauman
Affiliations
Review

The role of intrathecal drugs in the treatment of acute pain

James P Rathmell et al. Anesth Analg. 2005 Nov.

Abstract

Intrathecal opioids are widely used as useful adjuncts in the treatment of acute and chronic pain, and a number of non-opioid drugs show promise as analgesic drugs with spinal selectivity. In this review we examine the historical development and current use of intrathecal opioids and other drugs that show promise for treating pain in the perioperative period. The pharmacology and clinical use of intrathecal morphine and other opioids is reviewed in detail, including dosing guidelines for specific surgical procedures and the incidence and treatment of side effects associated with these drugs. Available data on the use of non-opioid drugs that have been tested intrathecally for use as analgesics are also reviewed. Evidence-based guidelines for dosing of intrathecal drugs for specific surgical procedures and for the treatment of the most common side effects associated with these drugs are presented.

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References

    1. Sydenham T Tractatus de podagra et hydrope. Geneva, 1686. In: Latham RG. The Works of Thomas Sydenham, MD, 3rd ed., Vol. 2. Birmingham, AL: Classics of Medicine Library, 1979.
    1. Goldstein A, Lowney LI, Pal BK. Stereospecific and nonspecific interactions of the morphine congener levorphanol in subcellular fractions of mouse brain. Proc Natl Acad Sci U S A 1971;68:1742–7.
    1. Pert CB, Snyder SH. Opiate receptor: demonstration in nervous tissue. Science 1973;179:1011–4.
    1. LaMotte C, Pert CB, Snyder SH. Opiate receptor binding in primate spinal cord: distribution and changes after dorsal root section. Brain 1976;112:407–12.
    1. Yaksh TL, Rudy TA. Analgesia mediated by a direct spinal action of narcotics. Science 1976;192:1357–8.

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