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. 2006 Aug;65(8):1055-9.
doi: 10.1136/ard.2005.041582. Epub 2005 Dec 8.

Urinary levels of type II collagen C-telopeptide crosslink are unrelated to joint space narrowing in patients with knee osteoarthritis

S A Mazzuca  1 , K D Brandt, D R Eyre, B P Katz, J Askew, K A Lane
Affiliations

Urinary levels of type II collagen C-telopeptide crosslink are unrelated to joint space narrowing in patients with knee osteoarthritis

S A Mazzuca et al. Ann Rheum Dis. 2006 Aug.

Abstract

Objective: To determine whether urinary concentrations of the cross linked C-telopeptide of type II collagen (CTx-II) distinguish subjects with progressive radiographic or symptomatic knee osteoarthritis from those with stable disease.

Subjects: were 120 obese women with unilateral knee osteoarthritis who participated in a 30 month, randomised, placebo controlled trial of structure modification by doxycycline, in which a standardised semiflexed anteroposterior view of the knee was obtained at baseline and 30 months. Subjects were selected from a larger sample to permit comparisons of urinary CTx-II levels between 60 progressors and 60 non-progressors with respect to medial joint space narrowing. Each group contained 30 subjects who, across five semi-annual assessments, reported on at least two occasions an increase of > or =20% in 50 ft walk pain (minimum = 1 cm on a 10 cm visual analogue scale), relative to the previous visit. The remainder reported no increases in knee pain. Urine samples were obtained semi-annually for determination of the CTx-II and creatinine concentrations.

Results: In an analysis of the placebo group only, the frequency of radiographic progressors in the upper and middle tertiles (48% and 60%, respectively) of the baseline CTx-II distribution was not significantly different than that in the lower tertile (64%). These results were unchanged after inclusion of data from subjects in the doxycycline group. Furthermore, serial CTx-II levels did not distinguish subjects with progressive radiographic or symptomatic knee osteoarthritis from those with stable disease.

Conclusions: In this pilot study, urinary CTx-II concentration was not a useful biomarker of osteoarthritis progression.

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References

    1. Poole A R. Biochemical/immunochemical biomarkers of osteoarthritis: utility for prediction of incident or progressive osteoarthritis. Rheum Dis Clin North Am 200329803–818. - PubMed
    1. Billinghurst R C, Dahlbert L, Ionescu M, Reiner A, Bourne R, Rorabeck C.et al Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage. J Clin Invest 1997991534–1545. - PMC - PubMed
    1. Dahlbert L, Billinghurst C, Manner P, Ionescu M, Reiner A, Tanzer M.et al Collagenase‐mediated cleavage of type II collagen is selectively enhanced in osteoarthritis cartilage and can be arrested with a synthetic inhibitor which spares collagenase‐1 (MMP‐1). Arthritis Rheum 200043673–682. - PubMed
    1. Squires G, Ionescu M, Okouneff S, Poole A R. The pathobiology of focal lesions development in aging human articular cartilage and molecular matrix changes characteristic of osteoarthritis. Arthritis Rheum 2003481261–1270. - PubMed
    1. Poole A R. Cartilage in health and disease. In: Koopman W, editor. Arthritis and allied conditions. A textbook of rheumatology, 14th edition. Philadelphia: Lippincott, Williams & Wilkins, 2001226–284.

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