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. 2005 Dec 9;310(5754):1641.
doi: 10.1126/science.1118357.

Increase in activity during calorie restriction requires Sirt1

Danica Chen  1 , Andrew D Steele, Susan Lindquist, Leonard Guarente
Affiliations

Increase in activity during calorie restriction requires Sirt1

Danica Chen et al. Science. .

Abstract

Sir2 (silent information regulator 2) is a nicotinamide adenine dinucleotide-dependent deacetylase required for longevity due to calorie restriction in yeast and Drosophila. In mammals, calorie restriction induces a complex pattern of physiological and behavioral changes. Here we report that the mammalian Sir2 ortholog, Sirt1, is required for the induction of a phenotype by calorie restriction in mice.

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  • Smaller, hungrier mice.
    Pani G, Fusco S, Galeotti T. Pani G, et al. Science. 2006 Mar 17;311(5767):1553-4; author reply 1553-4. doi: 10.1126/science.311.5767.1553. Science. 2006. PMID: 16543441 No abstract available.

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