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. 2005 Dec 9;310(5754):1661-5.
doi: 10.1126/science.1120367.

Rapid chiral assembly of rigid DNA building blocks for molecular nanofabrication

R P Goodman  1 , I A T Schaap, C F Tardin, C M Erben, R M Berry, C F Schmidt, A J Turberfield
Affiliations

Rapid chiral assembly of rigid DNA building blocks for molecular nanofabrication

R P Goodman et al. Science. .

Abstract

Practical components for three-dimensional molecular nanofabrication must be simple to produce, stereopure, rigid, and adaptable. We report a family of DNA tetrahedra, less than 10 nanometers on a side, that can self-assemble in seconds with near-quantitative yield of one diastereomer. They can be connected by programmable DNA linkers. Their triangulated architecture confers structural stability; by compressing a DNA tetrahedron with an atomic force microscope, we have measured the axial compressibility of DNA and observed the buckling of the double helix under high loads.

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