Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2005 Dec;4(12):1963-70.
doi: 10.1128/EC.4.12.1963-1970.2005.

Oligomerization of G-protein-coupled receptors: lessons from the yeast Saccharomyces cerevisiae

Mark C Overton  1 , Sharon L Chinault, Kendall J Blumer
Affiliations
Review

Oligomerization of G-protein-coupled receptors: lessons from the yeast Saccharomyces cerevisiae

Mark C Overton et al. Eukaryot Cell. 2005 Dec.
No abstract available

PubMed Disclaimer

Figures

FIG. 1.
FIG. 1.
Signal transduction by α-factor receptor dimers. In each model, α-factor receptor monomers (cyan and purple) form dimeric complexes in the plasma membrane as indicated by biophysical evidence (86). Each receptor monomer in a dimeric complex binds agonist (α-factor peptide, represented by spacefill), inducing conformational changes required for G protein activation. (A) Model in which two activated receptor subunits cooperate to activate one G protein heterotrimer (Gα subunit, Gpa1 in salmon; Gβγ heterodimer, Ste4 and Ste18 in green and light purple, respectively), possibly by contacting different regions of the G protein. (B) Model in which each receptor monomer in a dimeric complex activates a G protein heterotrimer. See text for further details.
See this image and copyright information in PMC

References

    1. Ayoub, M. A., C. Couturier, E. Lucas-Meunier, S. Angers, P. Fossier, M. Bouvier, and R. Jockers. 2002. Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer. J. Biol. Chem. 277:21522-21528. - PubMed
    1. Baker, E. K., N. J. Colley, and C. S. Zuker. 1994. The cyclophilin homolog NinaA functions as a chaperone, forming a stable complex in vivo with its protein target rhodopsin. EMBO J. 13:4886-4895. - PMC - PubMed
    1. Batlle, M., A. Lu, D. A. Green, Y. Xue, and J. P. Hirsch. 2003. Krh1p and Krh2p act downstream of the Gpa2p G(alpha) subunit to negatively regulate haploid invasive growth. J. Cell Sci. 116:701-710. - PubMed
    1. Benkirane, M., D. Y. Jin, R. F. Chun, R. A. Koup, and K. T. Jeang. 1997. Mechanism of transdominant inhibition of CCR5-mediated HIV-1 infection by ccr5delta32. J. Biol. Chem. 272:30603-30606. - PubMed
    1. Bermak, J. C., M. Li, C. Bullock, and Q. Y. Zhou. 2001. Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein. Nat. Cell Biol. 3:492-498. - PubMed

Publication types

MeSH terms

LinkOut - more resources