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. 1977 Jun 3;196(4294):1109-11.
doi: 10.1126/science.16343.

Direct resorption of bone by human monocytes

C R Mundy, A J Altman, M D Gondek, J G Bandelin

Direct resorption of bone by human monocytes

C R Mundy et al. Science. .

Abstract

Cultured human peripheral blood monocytes stimulate the release of bone mineral and matrix from killed long bones of fetal rats. These effects were inhibited by cortisol but were not altered by hormones that normally stimulate osteoclastic bone resorption. There was no evidence of morphologic differentiation of the monocytes into osteoclasts during bone resorption.

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