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Review
. 2006 Feb;18(1):10-5.
doi: 10.1016/j.coi.2005.11.009. Epub 2005 Dec 15.

Pentraxins as a key component of innate immunity

Barbara Bottazzi  1 , Cecilia Garlanda, Giovanni Salvatori, Pascale Jeannin, Angelo Manfredi, Alberto Mantovani
Affiliations
Review

Pentraxins as a key component of innate immunity

Barbara Bottazzi et al. Curr Opin Immunol. 2006 Feb.

Abstract

Pentraxins are a complex superfamily of multifunctional molecules characterized by a multimeric structure. C-reactive protein and pentraxin 3 (PTX3) are prototypic molecules of the short and long pentraxin family, respectively. PTX3 is conserved in evolution and produced by innate immune cells. Evidence suggests that PTX3 acts as a non-redundant component of the humoral arm of innate immunity, downstream of, and complementary to, cellular recognition, as well as a tuner of inflammation.

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