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. 2005 Dec 13;65(11):1802-4.
doi: 10.1212/01.wnl.0000191566.86977.04.

Alpha7-acetylcholine receptor antibodies in two patients with Rasmussen encephalitis

R Watson  1 , J E C Jepson, I Bermudez, S Alexander, Y Hart, K McKnight, A Roubertie, F Fecto, J Valmier, D B Sattelle, D Beeson, A Vincent, B Lang
Affiliations

Alpha7-acetylcholine receptor antibodies in two patients with Rasmussen encephalitis

R Watson et al. Neurology. .

Abstract

Rasmussen encephalitis (RE) sera were screened for antibodies to human alpha7 nicotinic acetylcholine receptors (nAChRs) using electrophysiology, calcium imaging, and ligand binding assays. Sera from two of nine patients with RE blocked ACh-induced currents through alpha7 nAChRs and the ACh-induced rise in intracellular free calcium ([Ca2+]i) and inhibited (125)I-alpha-bungarotoxin binding in cells expressing alpha7 nAChRs. Thus, the alpha7 nAChR is a potential target for pathogenic antibodies in patients with RE.

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