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. 2005 Dec 13;65(11):1823-5.
doi: 10.1212/01.wnl.0000187075.81589.fd.

BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study

S Karamohamed  1 , J C Latourelle, B A Racette, J S Perlmutter, G F Wooten, M Lew, C Klein, H Shill, L I Golbe, M H Mark, M Guttman, G Nicholson, J B Wilk, M Saint-Hilaire, A L DeStefano, R Prakash, S Tobin, J Williamson, O Suchowersky, N Labell, B N J Growdon, C Singer, R Watts, S Goldwurm, G Pezzoli, K B Baker, M L Giroux, P P Pramstaller, D J Burn, P Chinnery, S Sherman, P Vieregge, I Litvan, J F Gusella, R H Myers, A Parsian
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BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study

S Karamohamed et al. Neurology. .

Abstract

Brain-derived neurotrophic factor (BDNF) stimulates neuronal growth and protects nigral dopamine neurons in animal models of Parkinson disease (PD). Therefore, BDNF is a candidate gene for PD. The authors investigated five single-nucleotide polymorphisms in 597 cases of familial PD. Homozygosity for the rare allele of the functional BDNF G196A (Val66Met) variant was associated with a 5.3-year older onset age (p = 0.0001). These findings suggest that BDNF may influence PD onset age.

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