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. 1984 Feb;47(2):258-62.
doi: 10.1128/aem.47.2.258-262.1984.

Effects of Nitrapyrin [2-Chloro-6-(Trichloromethyl) Pyridine] on the Obligate Methanotroph Methylosinus trichosporium OB3b

E Topp  1 , R Knowles
Affiliations

Effects of Nitrapyrin [2-Chloro-6-(Trichloromethyl) Pyridine] on the Obligate Methanotroph Methylosinus trichosporium OB3b

E Topp et al. Appl Environ Microbiol. 1984 Feb.

Abstract

Nitrapyrin inhibited growth, CH(4) oxidation, and NH(4) oxidation, but not the oxidation of CH(3)OH, HCHO, or HCOONa, by Methylosinus trichosporium OB3b, suggesting that nitrapyrin acts against the methane monooxygenase enzyme system. The inhibition of CH(4) oxidation could be reversed by repeated washing of nitrapyrin-inhibited cells, indicating that its effect is bacteriostatic. The addition of Cu did not release the inhibition. Methane oxidation was also inhibited by 6-chloro-2-picoline. These data suggest that the mode of action of nitrapyrin on M. trichosporium is different from that on chemoautotrophic NH(4) oxidizers or methanogens.

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