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. 1986 Mar;51(3):493-7.
doi: 10.1128/aem.51.3.493-497.1986.

Trichothecene Biosynthesis in Fusarium sporotrichioides: Origin of the Oxygen Atoms of T-2 Toxin

A E Desjardins  1 , R D Plattner, F Vanmiddlesworth
Affiliations

Trichothecene Biosynthesis in Fusarium sporotrichioides: Origin of the Oxygen Atoms of T-2 Toxin

A E Desjardins et al. Appl Environ Microbiol. 1986 Mar.

Abstract

Mass spectral analysis of T-2 toxin formed during the growth of Fusarium sporotrichioides (ATCC 24043) in the presence of H(2)O showed incorporation of up to three O atoms per toxin molecule. The carbonyl oxygens of the acetates at C-4 and C-15 and of the isovalerate at C-8 were derived from H(2)O. Toxin formed in the presence of O molecular oxygen incorporated up to six O atoms per toxin molecule. The overall incorporation was 78 and 92% of toxin molecules labeled for H(2)O and O(2) labeled samples, respectively. The oxygens of position 1, the 12,13-epoxide, and the hydroxyl groups at C-3, C-4, C-8, and C-15 were all derived from molecular oxygen.

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References

    1. Science. 1981 Oct 16;214(4518):280-7 - PubMed

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