doi: 10.1126/science.163492.
Insulin-induced augmentation of lymphocyte-mediated cytotoxicity
- PMID: 163492
- DOI: 10.1126/science.163492
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Insulin-induced augmentation of lymphocyte-mediated cytotoxicity
Science.
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Abstract
Physiologic concentrations of insulin enhance the ability of cytotoxic lymphocytes to injure target cells. The effect of insulin closely resembles the action of cholinomimetics and guanosine 3',5'-monophosphate upon this system. Since both insulin and cholinomimetics elevate intracellular concentrations of guanosine 3',5'-monophosphate, a common mode of action is suggested.
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