Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1963 Jul;11(4):362-4.
doi: 10.1128/am.11.4.362-364.1963.

Sorbic Hydroxamic Acid, an Antifungal Agent Effective over a Wide pH Range

W F Dudman  1
Affiliations

Sorbic Hydroxamic Acid, an Antifungal Agent Effective over a Wide pH Range

W F Dudman. Appl Microbiol. 1963 Jul.

Abstract

Sorbic hydroxamic acid was prepared from sorbic acid by esterification and treatment with hydroxylamine (mp 133 to 135 C, pK(a) 8.8). Its ultraviolet spectrum in acid solution had a single absorption maximum at 262 mmu; in alkaline solution the maximal absorption shifted to 255 mmu and significant absorption appeared at 280 to 300 mmu. At concentrations of 0.1% (w/v), sorbic hydroxamic acid prevented the growth of Aspergillus niger, Penicillium notatum, Botrytis cinerea, Cladosporium herbarum, and a Rhizopus species in grape juice over the pH range 3.6 to 9.2, although sorbic acid was not effective at pH 5.7 and above.

PubMed Disclaimer

References

    1. Arzneimittelforschung. 1956 Apr;6(4):194-6 - PubMed
    1. Gruzlica. 1956 Apr;24(4):233-8 - PubMed
    1. Proc Soc Exp Biol Med. 1956 Aug-Sep;92(4):660-2 - PubMed
    1. Nature. 1957 Nov 30;180(4596):1204-5 - PubMed
    1. Gruzlica. 1958 Nov;26(11):889-917 - PubMed

LinkOut - more resources