Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Dec 21;127(50):17572-3.
doi: 10.1021/ja053799t.

MRI thermometry based on PARACEST agents

Shanrong Zhang  1 , Craig R Malloy, A Dean Sherry
Affiliations

MRI thermometry based on PARACEST agents

Shanrong Zhang et al. J Am Chem Soc. .

Abstract

A novel magnetic resonance imaging (MRI) thermometry technique is demonstrated in vitro based upon the use of a PARACEST (PARAmagnetic Chemical Exchange Saturation Transfer) agent. This new method takes advantage of the high concentration of bulk water (the readout signal for imaging) and the hyperfine frequency shift properties of PARACEST agents. For two prototypes, Dy(1)3+ and Eu(2)-, the chemical shifts (delta, in ppm) of the Ln3+-bound water molecules are linearly dependent on temperature (T, in degrees C) over the range of 20-50 degrees C (delta = 6.9 x T - 944.7 and delta = -0.4 x T + 64.6, respectively). This offers the exciting possibility of improving the temperature dependencies approximately 690- and approximately 40-fold over the most widely used water PRF thermometry (Proton Resonance Frequency: -0.01 ppm/ degrees C).

PubMed Disclaimer

Figures

Figure 1
Figure 1
Temperature maps of a phantom containing 1 mL of 10 mM Eu(2)- in water at pH 7.0. The temperatures of the air flowing over the sample are indicated in each figure while those reported by imaging are shown by the color bar (in units of °C).
Scheme 1
Scheme 1
Molecular structures of ligands 1 and 2.
Scheme 2
Scheme 2
A scheme illustrating the basic procedure for generating a temperature map based on PARACEST MRI thermometry.
See this image and copyright information in PMC

References

    1. Weidensteiner C, Quesson B, Caire-Gana B, Kerioui N, Rullier A, Trillaud H, Moonen Chrit TW. Magn Reson Med. 2003;50(2):322. - PubMed
    1. Levy S. Arch Mal Coeur Vaiss. 1995;88:1465. - PubMed
    1. Weinstein JN, Magin RL, Yatvin MB, Zaharko DS. Science. 1979;204:188. - PubMed
    1. Kim S. DRUGS IN R&D. 1993;46:618. - PubMed
    1. Madio D, van Gelderen P, Olson A, de Zwart J, Fawcett T, Holbrook N, Mandel M, Moonen C. J Magn Reson Imaging. 1998;8(1):101. - PubMed

Publication types