Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2005 Oct 5;7(2):E390-407.
doi: 10.1208/aapsj070240.

Modeling and simulation of adherence: approaches and applications in therapeutics

Leslie A Kenna  1 , Line Labbé, Jeffrey S Barrett, Marc Pfister
Affiliations
Review

Modeling and simulation of adherence: approaches and applications in therapeutics

Leslie A Kenna et al. AAPS J. .

Abstract

Partial adherence with a prescribed or randomly assigned dose gives rise to unintended variability in actual drug exposure in clinical practice and during clinical trials. There are tremendous costs associated with incomplete and/or improper drug intake-to both individual patients and society as a whole. Methodology for quantifying the relation between adherence, exposure and drug response is an area of active research. Modeling and statistical approaches have been useful in evaluating the impact of adherence on therapeutics and in addressing the challenges of confounding and measurement error which arise in this context. This paper reviews quantitative approaches to using adherence information in improving therapeutics. It draws heavily on applications in the area of HIV pharmacology.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Vrijens B, Tousset E, Gaillard P, Metry J, Urquhart J. Major features of dose omissions in 87 ambulatory drug trials. Clin Pharmacol Ther. 2005;77:99–99.
    1. Bond WS, Hussar DA. Detection methods and strategies for improving medication compliance. Am J Hosp Pharm. 1991;48:1978–1988. - PubMed
    1. Cramer JA, Spilker B, editors. Patient Compliance in Medical Practice and Clinical Trials. New York: Raven Press Ltd; 1991.
    1. Didlake RH, Dreyfus K, Kermanet RH, et al. Patient noncompliance: a major cause of late graft failure in cyclosporine-treated renal transplants. Transplant Proc. 1988;20(suppl 3):63–69. - PubMed
    1. Kastrissios H, Blaschke TF. Therapeutic implications of nonadherence with antiretroviral drug regimens. HIV. 1998;8:24–28.

MeSH terms