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. 2006 Jan 15;42(2):291-5.
doi: 10.1086/499056. Epub 2005 Dec 8.

Plasma levels of atazanavir and the risk of hyperbilirubinemia are predicted by the 3435C-->T polymorphism at the multidrug resistance gene 1

Sonia Rodríguez Nóvoa  1 , Pablo Barreiro, Ana Rendón, Ana Barrios, Angélica Corral, Inmaculada Jiménez-Nacher, Juan González-Lahoz, Vincent Soriano
Affiliations

Plasma levels of atazanavir and the risk of hyperbilirubinemia are predicted by the 3435C-->T polymorphism at the multidrug resistance gene 1

Sonia Rodríguez Nóvoa et al. Clin Infect Dis. .

Abstract

The 3435C-->T polymorphism at the multidrug resistance gene 1 (MDR1) was examined in 74 patients with human immunodeficiency virus who initiated atazanavir therapy. The MDR1 genotype distribution at position 3435 was 28% CC, 45% CT, and 27% TT. Plasma levels of atazanavir were significantly higher in patients with genotype CC than in those with CT or TT, and bilirubin levels correlated with atazanavir concentrations.

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