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Editorial
. 2006;8(1):101.
doi: 10.1186/ar1858.

Aging, osteoarthritis and transforming growth factor-beta signaling in cartilage

A Hari Reddi  1
Affiliations
Editorial

Aging, osteoarthritis and transforming growth factor-beta signaling in cartilage

A Hari Reddi. Arthritis Res Ther. 2006.

Abstract

Osteoarthritis is a common malady of the musculoskeletal system affecting the articular cartilage. The increased frequency of osteoarthritis with aging indicates the complex etiology of this disease, which includes pathophysiology and joint stability including biomechanics. The balance between anabolic morphogens and growth factors and catabolic cytokines is at the crux of the problem of osteoarthritis. One such signal is transforming growth factor-beta (TGF-beta). The impaired TGF-beta signaling has been identified as a culprit in old mice in a recent article in this journal. This commentary places this discovery in the context of anabolic and catabolic signals and articular cartilage homeostasis in the joint.

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References

    1. Reddi AH. Cartilage morphogenetic proteins: role in joint development, homoeostasis, and regeneration. Ann Rheum Dis. 2003;62(Suppl 2):ii73–ii88. - PMC - PubMed
    1. Davidson ENB, Schartstuhl A, Vitters EL, van der Kraan PM, van der Berg WB. Reduced transforming growth factor-beta signaling in cartilage of old mice: role in impaired repair capacity. Arthritis Res Ther. 2005;7:R1338–R1347. doi: 10.1186/ar1833. - DOI - PMC - PubMed
    1. ten Dijike P, Hill CS. New insights into TGF-β–Smad signaling. Trends Biochem Sci. 2004;29:265–273. doi: 10.1016/j.tibs.2004.03.008. - DOI - PubMed
    1. Feng XH, Derynck R. Specificity and versatility in TGF-β signaling through Smads. Annu Rev Cell Dev Biol. 2005;21:659–693. doi: 10.1146/annurev.cellbio.21.022404.142018. - DOI - PubMed
    1. Reddi AH. BMPs: from bone morphogenetic proteins to body morphogenetic proteins. Cytokine Growth Factor Rev. 2005;16:249–250. doi: 10.1016/j.cytogfr.2005.04.003. - DOI - PubMed

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