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Case Reports
. 2005 Sep 1;123(5):250-2.
doi: 10.1590/s1516-31802005000500010. Epub 2005 Dec 8.

Cellular angiofibroma of the vulva: case report with clinicopathological and immunohistochemistry study

Adilha Misson Rua Micheletti  1 , Ana Cristina Araújo Lemos da Silva, Antonio Geraldo Nascimento, Cléber Sérgio Da Silva, Eddie Fernando Candido Murta, Sheila Jorge Adad
Affiliations
Case Reports

Cellular angiofibroma of the vulva: case report with clinicopathological and immunohistochemistry study

Adilha Misson Rua Micheletti et al. Sao Paulo Med J. .

Abstract
in English, Portuguese

Context: Cellular angiofibroma of the vulva is a rare tumor that was first described in 1997. It occurs in middle-aged women (average age: 47 years), has small size (< 3 cm) and well-circumscribed margins.

Case report: We describe a case in a 51-year-old woman whose preoperative diagnosis was confounded with Bartholin's glandular cyst. The neoplasia was well delimited and made up of three characteristic components: fusiform cells forming small fascicles, numerous blood vessels and adipose tissue interspersed between the fusiform cells. The stroma cells were positive for vimentin and negative for CD34, protein S-100, actin and desmin. The differential diagnoses for this tumor include aggressive angiomyxoma, angiomyofibroblastoma, lipoma of fusiform cells, solitary fibrous tumor, perineurioma and leiomyoma.

CONTEXTO:: O angiofibroma celular da vulva é um tumor raro que foi inicialmente descrito em 1997. Ocorre em mulheres de meia-idade (média de idade: 47 anos), apresentar pequeno tamanho (< 3 cm) e margem bem circunscrita.

RELATO DE CASO:: Descrevemos um caso em mulher de 51 anos de idade cujo diagnóstico pré-operatório foi confundido com cisto de glândula de Bartholin. A neoplasia era bem delimitada e constituída por três componentes característicos: células fusiformes formando pequenos fascículos, numerosos vasos sangüíneos e tecido adiposo entremeado às células fusiformes. As células do estroma eram positivas para vimentina e negativas para CD34, proteína S-100, actina e desmina. O diagnóstico diferencial deste distinto tumor inclui angiomixoma agressivo, angiomiofibroblastoma, lipoma, tumor fibroso solitário, perineurioma, e leiomioma.

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Conflict of interest statement

Conflict of interest: Not declared

Figures

Figure 1
Figure 1. Photomicrograph of the angiofibroma showing its three characteristic components: fusiform cells, blood vessels and adipose tissue (hematoxylin-eosin; 4 X).
Figure 2
Figure 2. Small to medium size vessels with hyalinized walls, showing fusiform cells with bland nuclei and clear cytoplasm in an angiofibroma tumor (hematoxylin-eosin; 20 X).
See this image and copyright information in PMC

References

    1. Nucci MR, Granter SR, Fletcher CD. Cellular angiofibroma: a benign neoplasm distinct from angiomyofibroblastoma and spindle cell lipoma. Am J Surg Pathol. 1997;21(6):636–644. - PubMed
    1. Nucci MR, Fletcher CD. Vulvovaginal soft tissue tumours: update and review. Histopathology. 2000;36(2):97–108. - PubMed
    1. Garijo MF, Val-Bernal JF. Extravulvar subcutaneous cellular angiofibroma. J Cutan Pathol. 1998;25(6):327–332. - PubMed
    1. Laskin WB, Fetsch JF, Mostofi FK. Angiomyofibroblastoma-like tumor of the male genital tract: analysis of 11 cases with comparison to female angiomyofibroblastoma and spindle cell lipoma. Am J Surg Pathol. 1998;22(1):6–16. - PubMed

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