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Randomized Controlled Trial
. 2006 Jan;48(1):10-3.
doi: 10.1017/S0012162206000041.

Treatment of adductor spasticity with BTX-A in children with CP: a randomized, double-blind, placebo-controlled study

Volker Mall  1 , Florian Heinen, Andrea Siebel, Christoph Bertram, Ulrich Hafkemeyer, Jörg Wissel, Steffen Berweck, Fritz Haverkamp, Günter Nass, Leo Döderlein, Nico Breitbach-Faller, Wilhelm Schulte-Mattler, Rudolf Korinthenberg
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Free article
Randomized Controlled Trial

Treatment of adductor spasticity with BTX-A in children with CP: a randomized, double-blind, placebo-controlled study

Volker Mall et al. Dev Med Child Neurol. 2006 Jan.
Free article

Abstract

Adductor spasticity in children with cerebral palsy (CP) impairs motor function and development. In a placebo-controlled, double-blind, randomized multicentre study, we evaluated the effects of botulinum toxin A(BTX-A) in 61 children (37 males, 24 females; mean age 6 years 1 month [SD 3y 1mo]) with CP (leg-dominated tetraparesis, n=39; tetraparesis, n=22; GMFCS level I, n=3; II, n=6; III, n=17; IV, n=29; V, n=6). Four weeks after treatment, a significant superiority of BTX-A was observed in the primary outcome measure (knee-knee distance 'fast catch', p=0.002), the Ashworth scale (p=0.001), and the Goal Attainment Scale (p=0.037).

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